The Senate just confirmed Kathleen Sebelius as Obama’s secretary of Health and Human Services. Eight Republicans, plus Specter, joined the Democrats. Notably, in addition to the usual suspects (Collins, Snowe), anti-abortion Sen. Sam Brownback voted to confirm his fellow (but abortion-supporting) Kansan. He wants her job as governor of the Sunflower State, but with votes like this, his socially conservative base may start to have second thoughts. On the other hand, the socially liberal Republicans who helped elect Sebelius in the first place might warm up to him. Pat Roberts, the other Republican senator from Kansas, also voted to confirm.
See Michael Brendan Dougherty’s recent article  for why Sebelius is worse than your standard pro-abortion pol.